Windows 7 / 8.x / 10 users (32-bit and 64-bit) can download the installer (as listed above). The installer automatically downloads the needed requirements if missing.
After the installation you can start Smuxi from the Windows Start Menu.
If the auto install fails for some reason, you can download the components manually from here:
After you have installed GTK# 2.12 for .NET manually you must reboot (or re-logon) your Windows!